When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in periphe...
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Is normal language acquisition possible in spite of serious intellectual impairment? The answer, it would appear, is positive. This book summarizes and discusses recent evidence in this respect. The b...