Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome...
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The new field of spatial history has been driven by digital mapping tools, which can readily show change over time in space. But long before this software was developed, mapmakers around the world rep...